acl adserver_regex dstdom_regex -i ^ad\. ^ads\.
http_access deny adserver_regex
is nice to have, just to give an example. The 'Access Denied' Error Page that squid will deliver in case of a blocked add might be replaced to something more eyecandy / non-technical output for the common user.
www.squid-cache.org
pgl.yoyo.org/adservers/